Premarin Timeline 2015

FEBRUARY 19, 2015


The groundbreaking article, “Women have been oversold HRT for decades“, by Margaret McCartney, published by The Guardian newspaper, is always worth a read.

Excerpted here, McCartney writes:

On my desk I keep a copy of Feminine Forever, a book promoting hormone replacement therapy (HRT), published in 1966, by Robert A Wilson. On the front, it proclaims that it is “a fully documented discussion of one of medicine’s most revolutionary breakthroughs – the discovery that the menopause is a hormone deficiency disease, curable and totally preventable and that every woman, no matter what her age, can safely live a fully sexed life for her entire life”.

I keep this book to remind me of a few things. One, that it is possible to be very, dramatically wrong in medicine – especially when you are very sure of yourself. Two, that when you make big promises, you should have robust, unbiased and powerful data to support them. Three, that when medicine tries to suggest that a new large section of the population – on this occasion, that all women over menopausal age — are “diseased”, one had better look to see who is behind that claim, and why. And last, hype around new medical products are, sadly, nothing new.

As a junior doctor more than two decades ago, I attended meetings (which had sandwiches, pens and soft drinks supplied by drug companies, I am sorry to say) where HRT was promoted as not just the dream solution to all menopausal symptoms – but the way to prevent cardiovascular disease, dementia, stress incontinence, hair loss, the need for dentures, and osteoporosis. There were even claims made that it could prevent depression and supposedly restore a sex life back to ecstatic peaks. Wilson suggested that women should start hormone replacement in their mid-30s, claimed that “the myth that oestrogen is a causative factor in cancer has been proven to be entirely false” and that it would generate “youthful appearance and vigorous energy”, else poor ladies would simply “crumble in ruin”. It took until 2002 for it to emerge that Wilson was being funded by Wyeth, a major manufacturer of HRT — a fact not disclosed in the book.

HRT is still widely recommended for treatment of menopausal symptoms – particularly hot flushes and night sweats — but with the mantra of “informed choice”. Properly informed choice needs accurate information. The initial promises made that HRT could reduce future cardiovascular disease were based on observational studies. Observational studies, though, are highly prone to bias, wrong conclusions, and thus bad information. High-quality, reliable, clinical data is best generated by double-blind, randomised controlled trials that compare groups, with the only difference being the drug under test, and careful attention to monitoring benefits and harms. One such trial, the Hers study, published in 1998, found that recurrent cardiovascular disease wasn’t prevented by HRT. Then — to shock, surprise and dismay — the Women’s Health Initiative Study, published in 2002, found that the risk of cardiovascular disease was in fact increased with HRT, not decreased.

For 10,000 people-years of taking HRT, there were 15 more heart attacks or strokes, eight more pulmonary emboli — blood clots to the lungs — and eight more breast cancers. Last week, an analysis published in the Lancet found that for every 1,000 women using HRT for five years, there is one extra case of ovarian cancer — a slightly higher risk than seen in previous studies.

This week another study was also published which found that, of women who have frequent hot flushes and sweats due to the menopause, the average duration of symptoms was just over seven years. It seems that the length of time that symptoms go on for has been underestimated by doctors (but not women, if anyone had listened) — thanks to a historical lack of quality studies on such basic knowledge. And isn’t it the basics that we need to get right first, so that we can advise women properly?

Read full article »

PDF 2 pp 75 KB
Women_Oversold_HRT_for_Decades_by_Margaret_McCartney »

MAY 9, 2015


Menopausal hormone use and ovarian cancer risk: individual participant meta-analysis of 52 epidemiological studies

Collaborative Group on Epidemiological Studies of Ovarian Cancer, Oxford, England

— Background

Half the epidemiological studies with information about menopausal hormone therapy and ovarian cancer risk remain unpublished, and some retrospective studies could have been biased by selective participation or recall. We aimed to assess with minimal bias the effects of hormone therapy on ovarian cancer risk.

— Interpretation of Findings

The increased risk may well be largely or wholly causal; if it is, women who use hormone therapy for 5 years from around age 50 years have about one extra ovarian cancer per 1000 users and, if its prognosis is typical, about one extra ovarian cancer death per 1700 users.

Link to source »  View PDF 8pp »


Premarin, Prempro, Premphase and Duavee are examples of the Premarin family of drugs which are made with the the estrogen rich urine of pregnant mares.

In the ‘pregnant mare urine’ (PMU) industry, horses are repeatedly impregnated so their urine can be collected and made into hormone replacement products . Some of the foals are rescued , but most are simply slaughtered and seen as a byproduct (much like male calves in the dairy industry).

There are alternatives. Talk to your doctor. Visit your local pharmacy. There are prescription free over-the-counter treatments for hot flashes, vaginal dryness and other menopausal symptoms. Thank you.

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